SelectMDx risk scores correlate with multiparametric MRI outcomes
What was studied?
This study assessed the association between SelectMDx and multiparametric (mp)MRI outcomes.
What were the main outcomes?
The median SelectMDx risk score was statistically significantly higher in men who had a suspicious lesion on mpMRI compared to those who had a normal MRI (P<0.01). Moreover, a positive correlation was found between the SelectMDx risk score and the PI-RADS classification. The difference in SelectMDx risk scores between the different PI-RADS groups was statistically significant (P<0.001).
(PI-RADS: Prostate Imaging Reporting and Data System)
What was concluded?
This study showed that SelectMDx risk scores correlate with mpMRI outcomes and PI-RADS grading. This suggests that SelectMDx can help to select patients for further diagnostics such as MRI and identify men at risk for clinically significant prostate cancer.
How was the study performed?
This was a retrospective cohort study that included 174 patients that were previously included in the SelectMDx validation study . Urine was collected after a DRE for the SelectMDx test. Patients underwent a mpMRI for persistent suspicion of prostate cancer after negative biopsies or for staging after finding prostate cancer on biopsy.
Want to read more?
Full publication recently released: Hendriks RJ et al. Prostate 2017. doi: 10.1002/pros.23401